I recently upgraded to Mac OSX Lion 10.7.1 and right away started having issues. The main problem I had was my Mac Mail program slowed down to a crawl and would even freeze, forcing me to do a Force Quit. I also was unable to run my Espionage program, so I wasn't able to unlock my Mail program to see if that was the problem.
I uninstalled the Espionage program, which completely locked me out of the Mail program from even running, I then reinstalled Espionage and added the Mail program back to it for Locking, rebooted the system, and then reopened Espionage, Unlocked the Mail and Mail download folders, and all systems worked fine afterwards.
What I would of done differently, I would of Unlocked ALL folders and programs through Espionage, BEFORE loading the new OSX Lion, then rebooted, made sure Espionage could open and run effectively, and re-lock my chosen folders and programs.
I haven't tried to re-lock my Mail program via espionage yet, but I will soon and if I start to have issues again, I'll keep you all posted.